Cortisone Shots: Relief, Risks, and What to Expect

A comprehensive guide to cortisone shots, their uses, benefits, risks, and what patients should know before treatment.

By Sneha Tete, Integrated MA, Certified Relationship Coach
Created on

Cortisone Shots Overview

Cortisone shots are a medical procedure used to relieve pain, swelling, and irritation in a localized area of the body. This treatment is most commonly administered into joints such as the ankle, elbow, hip, knee, shoulder, spine, or wrist. Even the smaller joints of the hands and feet can benefit from cortisone injections. Cortisone shots often combine a corticosteroid (for longer-term pain relief) and a local anesthetic (for immediate pain relief). Most cortisone injections are done in a doctor’s office and, due to the potential for side effects, the number of shots given annually is typically limited.

Why Cortisone Shots Are Given

Cortisone shots are particularly effective for inflammatory conditions and are most often used in the treatment of inflammatory arthritis, such as rheumatoid arthritis. They are also part of management plans for a variety of other issues, including:

  • Back pain
  • Bursitis
  • Gout
  • Osteoarthritis
  • Psoriatic arthritis
  • Tendinitis

This range of uses makes cortisone injections a popular option for localized musculoskeletal pain and inflammation relief.

How the Procedure Is Performed

Receiving a cortisone injection usually does not require hospital admission. The steps usually include:

  • Cleansing: The injection site is thoroughly cleaned to prevent infection.
  • Anesthesia: An anesthetic spray may be applied to numb the area where the needle will be inserted.
  • Needle Guidance: Your healthcare provider may use ultrasound or fluoroscopy (a type of X-ray) to guide the needle accurately.
  • Medication Injection: The corticosteroid (for inflammation reduction and pain relief) and local anesthetic (for immediate numbing) are injected.

Most patients are able to leave the office shortly after the procedure. The inclusion of local anesthetic provides prompt relief, while the corticosteroid takes effect more gradually over several days.

Expected Results of Cortisone Shots

Cortisone shots are well-known for their ability to provide significant pain relief. However, responses can vary, depending on the underlying condition and individual patient factors. Feelings of increased pain, swelling, and irritation may occur at the injection site immediately after the shot. This “flare” usually lasts for no more than two days. Following this, symptoms should decrease. The duration of pain relief often ranges:

  • For some, relief may last only a few weeks.
  • Others may enjoy several months or longer with reduced symptoms.

Cortisone shots commonly help with joint pain, tenderness, stiffness, and swelling. It is important to note that while the injections can provide substantial symptom improvement, they are typically part of a broader management program and not a permanent cure.

Potential Risks and Side Effects

Although cortisone shots are generally considered safe, they do carry risks. Side effects can be more likely with higher doses or frequent injections. Below is a list of possible risks:

  • Short-term flare: Temporary pain and swelling at the injection site, usually resolving within 48 hours.
  • Skin changes: Thinning or loss of color in skin near the injection area.
  • Cartilage damage: Repeated injections may lead to cartilage breakdown within the joint.
  • Nerve damage: Rare but possible, depending on injection site.
  • Joint infection: Uncommon but serious, requiring prompt medical evaluation.
  • Tendon weakening: Especially when injections are near tendons.
  • Bone thinning: Extended use may lead to bone density losses.

Most side effects are temporary, but rare longer-lasting complications can negatively impact joint and surrounding tissue health. Blood thinners and certain supplements may need to be stopped before receiving a cortisone shot to reduce bleeding or bruising risk. Always check with your healthcare provider regarding which medications or supplements to avoid.

Limits on Cortisone Shot Frequency

Due to the risk of cartilage damage and other potential complications, healthcare providers set limits on the number and frequency of cortisone injections:

  • Typically no more than one injection every six weeks per affected joint.
  • Most guidelines recommend no more than three or four injections per joint per year.
  • The exact number may vary depending on the diagnosis, joint involved, and individual patient health.

Discuss the risks and benefits with your provider to determine the safest approach.

Benefits of Cortisone Shots

  • Rapid relief: The anesthetic provides immediate numbing, and the steroid helps decrease inflammation over time.
  • Non-surgical treatment: Effective for many inflammatory conditions without the need for invasive procedures.
  • Targeted: Injections can focus on a specific problem area for maximum effect.

Cortisone shots are particularly valuable for those whose joint pain and inflammation negatively impacts their daily function and quality of life.

Who Should Avoid Cortisone Shots?

Cortisone shots may not be appropriate for everyone. Caution or avoidance is recommended for:

  • Individuals with active joint infections.
  • Those who have allergy to components of the injection.
  • Patients taking blood-thinning medication unless cleared by a provider.
  • People with certain metabolic or bone conditions (at provider discretion).

Always inform your healthcare team about your medications and medical history prior to treatment.

Preparing for Cortisone Shots

To support a safe injection, patients may need to:

  • Stop certain medications, including blood thinners and supplements, prior to the procedure.
  • Fast or alter dietary intake, if directed by provider.
  • Arrange for transportation if concerned about post-injection pain or discomfort.

Consult your doctor for exact instructions before your appointment.

Long-Term Use and Repeat Injections

While cortisone injections can be repeated if pain relief is substantial and lasts at least a few weeks to months, long-term or frequent use is not recommended. Over time, multiple injections—especially within the same joint—may contribute to cartilage deterioration and permanent damage. Providers frequently limit repeat injections and encourage integrating physical therapy and rehabilitative support as part of overall care.

Balancing Benefits and Risks

BenefitsRisks
Decrease inflammationTemporary pain flare
Rapid joint pain reliefCartilage damage (with repeated use)
Improve function, mobilitySkin changes near site
Effective non-surgical optionNerve/tendon injury (rare)
Short office procedureRisk of joint infection

Frequently Asked Questions (FAQs) on Cortisone Shots

Q: How quickly do cortisone shots work?

The local anesthetic provides relief within hours, while the corticosteroid typically shows benefits over several days.

Q: How long does pain relief last?

Pain relief varies, lasting from a few weeks to several months, depending on diagnosis and individual response.

Q: Can cortisone shots harm the cartilage?

Repeated injections may damage cartilage, which is why doctors limit frequency and total annual dose.

Q: What conditions benefit most from cortisone shots?

Conditions such as rheumatoid arthritis, osteoarthritis, gout, bursitis, psoriatic arthritis, tendinitis, and localized back pain.

Q: What are alternatives to cortisone shots?

Alternatives include oral anti-inflammatory medications, physical therapy, rest, bracing, and surgical intervention for severe cases.

Q: Are there restrictions before or after the procedure?

You may need to stop blood thinners or certain supplements and avoid vigorous activity at the injection site immediately after the procedure.

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References

  • Information synthesized from Mayo Clinic Health Library and Mayo Clinic News Network.
Sneha Tete
Sneha TeteBeauty & Lifestyle Writer
Sneha is a relationships and lifestyle writer with a strong foundation in applied linguistics and certified training in relationship coaching. She brings over five years of writing experience to LifePortico,  crafting thoughtful, research-driven content that empowers readers to build healthier relationships, boost emotional well-being, and embrace holistic living.

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